| This Wk | Last Wk | Movies List | Dist. | Weekend Gross | Cumulative Gross | Rlse Wks | # of Theaters | | 1 | - | Quantum Of Solace | Sony Pictures Releasing | $67,528,882 | $67,528,882 | 1 | 3451 |
| 2 | 1 | Madagascar: Escape 2 Africa | DreamWorks, Paramount Pictures | $35,017,301 | $116,905,195 | 2 | 4065 |
| 3 | 2 | Role Models | Universal Pictures | $11,150,030 | $37,577,245 | 2 | 2798 |
| 4 | 3 | High School Musical 3: Senior Year | Buena Vista Pictures Distribution | $5,656,162 | $84,169,216 | 4 | 3202 |
| 5 | 4 | Changeling | Universal Pictures | $4,254,080 | $27,631,772 | 4 | 1896 |
| 6 | 5 | Zack and Miri Make a Porno | Dimension Films, The Weinstein Company | $3,146,312 | $26,465,482 | 3 | 2210 |
| 7 | 6 | Soul Men | MGM Distribution Company | $2,350,141 | $9,370,925 | 2 | 2048 |
| 8 | 9 | The Secret Life of Bees | Fox Searchlight Pictures | $2,338,279 | $33,627,359 | 5 | 1449 |
| 9 | 7 | Saw V | Lionsgate | $1,767,405 | $55,380,488 | 4 | 2002 |
| 10 | 11 | Beverly Hills Chihuahua | Buena Vista Pictures Distribution | $1,579,080 | $90,878,127 | 7 | 1617 |
| 11 | 10 | Eagle Eye | Paramount Pictures | $1,463,140 | $98,738,396 | 8 | 1214 |
| 12 | 8 | The Haunting of Molly Hartley | Freestyle Releasing | $1,438,561 | $12,484,484 | 3 | 1587 |
| 13 | 13 | Fireproof | Samuel Goldwyn Films, Affirm Films | $1,255,877 | $30,198,386 | 8 | 862 |
| 14 | 15 | Rachel Getting Married | Sony Pictures Classics | $1,051,365 | $6,945,965 | 7 | 390 |
| 15 | 14 | Body of Lies | Warner Bros. Pictures Distribution | $674,495 | $38,246,741 | 6 | 625 |
| 16 | - | Dostana | N/A | $645,604 | $645,604 | 1 | 74 |
| 17 | 12 | Max Payne | 20th Century Fox Distribution | $620,337 | $39,963,832 | 5 | 845 |
| 18 | 30 | The Dark Knight | Warner Bros. Pictures Distribution | $502,334 | $529,143,070 | 18 | 346 |
| 19 | 28 | The Boy in the Striped Pajamas | Miramax Films | $474,390 | $827,683 | 2 | 38 |
| 20 | 19 | Appaloosa | Warner Bros. Pictures Distribution | $454,518 | $19,413,695 | 9 | 737 |
| 21 | 17 | W. | Lionsgate | $444,210 | $25,134,292 | 5 | 505 |
| 22 | 16 | Pride and Glory | Warner Bros. Pictures Distribution | $410,530 | $15,371,091 | 4 | 575 |
| 23 | 22 | Happy-Go-Lucky | Miramax Films | $370,651 | $1,760,854 | 6 | 143 |
| 24 | - | Slumdog Millionaire | Fox Searchlight Pictures | $360,018 | $427,715 | 1 | 10 |
| 25 | 18 | RocknRolla | Warner Bros. Pictures | $343,980 | $5,245,837 | 6 | 548 |
| 26 | 26 | Synecdoche, New York | Sony Pictures Classics | $331,778 | $1,123,224 | 4 | 80 |
| 27 | 21 | The Duchess | Paramount Vantage | $236,779 | $13,445,348 | 9 | 270 |
| 28 | 20 | Religulous | Lionsgate | $230,474 | $12,550,842 | 7 | 238 |
| 29 | 24 | Nights in Rodanthe | Warner Bros. Pictures Distribution | $212,563 | $41,288,655 | 8 | 314 |
| 30 | 23 | Burn After Reading | Focus Features | $195,748 | $59,850,794 | 10 | 207 |
| 31 | 31 | WALL-E | Buena Vista Pictures Distribution | $192,392 | $223,280,427 | 21 | 223 |
| 32 | 32 | I've Loved You So Long | Sony Pictures Classics | $163,344 | $989,361 | 4 | 31 |
| 33 | 27 | Quarantine | Sony Pictures Releasing | $131,781 | $31,691,811 | 6 | 193 |
| 34 | 38 | Let the Right One In | Magnet | $123,858 | $439,906 | 4 | 26 |
| 35 | 29 | Nick & Norah's Infinite Playlist | Sony Pictures Releasing | $121,289 | $31,487,293 | 7 | 133 |
| 36 | 34 | City of Ember | Fox Walden | $97,067 | $7,571,177 | 6 | 171 |
| 37 | 25 | House | Roadside Attractions | $83,915 | $530,328 | 2 | 234 |
| 38 | 35 | Journey to the Center of the Earth | Warner Bros. Pictures Distribution | $74,722 | $101,590,877 | 19 | 149 |
| 39 | 62 | JCVD | Peace Arch Entertainment Group | $68,357 | $95,422 | 2 | 28 |
| 40 | - | A Christmas Tale | IFC Films | $63,837 | $63,837 | 1 | 7 |
| 41 | 61 | Space Station 3-D | IMAX Corporation | $60,038 | $76,939,202 | 344 | 6 |
| 42 | 33 | What Just Happened | Magnolia Pictures | $58,888 | $995,155 | 5 | 62 |
| 43 | 39 | Vicky Cristina Barcelona | MGM Distribution Company, The Weinstein Company | $55,950 | $22,345,826 | 14 | 39 |
| 44 | 43 | Igor | The Weinstein Company, Metro-Goldwyn-Mayer Studios Inc. (MGM) | $49,463 | $19,048,181 | 9 | 78 |
| 45 | 51 | Sea Monsters: A Prehistoric Adventure | N/A | $47,318 | $19,783,110 | 59 | 21 |
| 46 | 41 | Righteous Kill | Overture Films | $44,127 | $39,705,189 | 10 | 108 |
| 47 | 49 | Deep Sea 3D | Warner Bros. Pictures Distribution | $40,068 | $36,889,629 | 142 | 10 |
| 48 | 40 | Traitor | Overture Films | $39,544 | $23,501,463 | 12 | 124 |
| 49 | 45 | Tim Burton s The Nightmare Before Christmas | Buena Vista Pictures Distribution | $38,496 | $1,096,037 | 4 | 37 |
| 50 | 42 | Sex Drive | Summit Entertainment, LLC | $34,959 | $8,302,193 | 5 | 62 |
| 51 | 44 | Noah s Arc: Jumping the Broom | Logo Features | $32,313 | $451,141 | 4 | 7 |
| 52 | 53 | Tell No One | Music Box Film | $23,326 | $6,071,209 | 20 | 29 |
| 53 | 54 | Dolphins and Whales 3D: Tribes of the Ocean | 3D Entertainment Distribution Ltd. | $23,106 | $5,055,805 | 40 | 11 |
| 54 | 73 | Miracle at St. Anna | Buena Vista Pictures Distribution | $22,112 | $7,898,010 | 8 | 76 |
| 55 | 47 | Fly Me to the Moon 3-D | Summit Entertainment, LLC | $21,237 | $12,242,600 | 14 | 27 |
| 56 | 57 | Magnificent Desolation: Walking on the Moon 3D | IMAX Corporation | $19,650 | $26,457,831 | 165 | 5 |
| 57 | 46 | Repo! The Genetic Opera | Lionsgate | $19,029 | $90,828 | 2 | 8 |
| 58 | 56 | Man on Wire | Magnolia Pictures, Discovery Channel Productions | $16,953 | $2,839,724 | 17 | 15 |
| 59 | 58 | The Longshots | Metro-Goldwyn-Mayer Studios Inc. (MGM) | $16,814 | $11,491,806 | 13 | 36 |
| 60 | 52 | A Secret | Strand Releasing | $16,745 | $480,054 | 11 | 7 |
| 61 | 63 | Frozen River | Sony Pictures Classics | $15,562 | $2,261,468 | 16 | 26 |
| 62 | 70 | Morning Light | Buena Vista Pictures Distribution | $13,692 | $266,410 | 5 | 21 |
| 63 | 60 | My Name is Bruce | Dark Horse Entertainment, Image Entertainment | $13,336 | $71,780 | 3 | 4 |
| 64 | - | Familiar Strangers | Sky Island Films | $11,553 | $11,553 | 1 | 2 |
| 65 | 75 | Roving Mars | Buena Vista Pictures Distribution | $10,612 | $9,735,460 | 147 | 6 |
| 67 | 55 | The Women | Picturehouse | $10,000 | $26,896,744 | 10 | 26 |
| 68 | 69 | Stranded: I've Come From a Plane That Crashed in the Mountains | Zeitgeist Films | $8,609 | $36,842 | 4 | 5 |
| 69 | 66 | Ashes of Time Redux | Sony Pictures Classics | $7,356 | $140,082 | 6 | 15 |
| 70 | 79 | Pray the Devil Back to Hell | Balcony Releasing | $7,310 | $17,244 | 2 | 3 |
| 71 | 83 | I Served the King of England | Sony Pictures Classics | $7,065 | $566,103 | 12 | 16 |
| 72 | 81 | U2 3D | National Geographic World Films | $6,710 | $9,621,034 | 43 | 6 |
| 73 | 93 | Space Chimps | 20th Century Fox Distribution | $6,315 | $30,100,188 | 18 | 17 |
| 74 | 114 | The First Basket | Laemmle/Zeller Films | $6,090 | $11,812 | 3 | 3 |
| 75 | - | The Dukes | CAVU Pictures | $6,067 | $6,067 | 1 | 4 |
| 76 | - | How About You | Strand Releasing | $6,022 | $6,022 | 1 | 1 |
| 77 | 78 | A Girl Cut in Two | First Take (IFC) | $5,639 | $376,719 | 14 | 11 |
| 78 | 89 | Ballast | Alluvial Film Company | $5,552 | $64,895 | 7 | 5 |
| 79 | 71 | The Alphabet Killer | New Films International, Anchor Bay Entertainment | $5,123 | $21,139 | 2 | 2 |
| 80 | 96 | Fear(s) of the Dark | IFC Films | $4,859 | $58,512 | 4 | 4 |
| 81 | 67 | Trouble the Water | Zeitgeist Films | $4,806 | $460,102 | 13 | 8 |
| 82 | 97 | Hounddog | Empire Film Group | $4,650 | $117,204 | 9 | 2 |
| 83 | 80 | Choke | Fox Searchlight Pictures | $4,642 | $2,921,022 | 8 | 19 |
| 84 | 76 | Mirrors | 20th Century Fox | $4,565 | $30,689,603 | 14 | 11 |
| 85 | 48 | Fashion | UTV Motion Pictures | $4,191 | $191,442 | 3 | 13 |
| 86 | 68 | Call + Response | Fair Trade Pictures | $3,731 | $170,615 | 6 | 3 |
| 87 | 64 | The Other End of the Line | Metro-Goldwyn-Mayer Studios Inc. (MGM), MGM Distribution Company | $3,377 | $110,817 | 3 | 5 |
| 88 | 86 | I.O.U.S.A. | Roadside Attractions | $3,258 | $797,433 | 13 | 7 |
| 89 | 98 | Flow | Oscilloscope Pictures | $3,100 | $134,284 | 21 | 5 |
| 90 | - | Eden | Liberation Entertainment | $3,084 | $3,084 | 1 | 1 |
| 91 | 91 | My Father My Lord | Kino International | $3,044 | $199,829 | 27 | 5 |
| 92 | - | The Beautiful Truth | N/A | $3,025 | $3,025 | 1 | 1 |
| 93 | - | Good Dick | Morning Knight, Present Pictures | $3,020 | $27,595 | 6 | 2 |
| 94 | 84 | The Wild Child | MGM Distribution Company, The Film Desk, Heathen Films | $2,669 | $15,360 | 2 | 1 |
| 95 | 77 | The World Unseen | Regent Releasing | $2,364 | $13,795 | 2 | 3 |
| 96 | 94 | Babylon A.D. | 20th Century Fox Distribution | $2,284 | $22,531,698 | 12 | 9 |
| 97 | 109 | Battle in Seattle | ThinkFilm, Redwood Palms Pictures | $2,182 | $220,038 | 9 | 10 |
| 98 | 74 | August Evening | Maya Entertainment | $2,089 | $66,233 | 11 | 4 |
| 99 | 85 | Dear Zachary: A Letter to a Son About His Father A Letter to a Son About His Father | Oscilloscope Pictures, MSNBC Films | $1,800 | $18,334 | 3 | 3 |
| 100 | - | House of the Sleeping Beauties | First Run Features | $1,535 | $1,535 | 1 | 1 |
| 101 | 120 | The Flyboys | N/A | $1,475 | $133,696 | 14 | 2 |
| 102 | - | Antarctica | Regent Releasing | $1,213 | $1,213 | 3 | 1 |
| 103 | 125 | America the Beautiful | Sensory Overload Entertainment, Arenas Entertainment, First Independent Pictures | $1,134 | $75,484 | 28 | 1 |
| 104 | 116 | How to Lose Friends & Alienate People | MGM Distribution Company | $1,086 | $2,759,150 | 7 | 5 |
| 105 | 130 | Momma's Man | ThinkFilm, Kino International | $1,014 | $92,178 | 13 | 1 |
| 106 | 101 | Gardens of the Night | City Lights Media Group | $780 | $4,831 | 2 | 1 |
| 107 | 111 | In Search of a Midnight Kiss | First Take (IFC) | $665 | $172,177 | 16 | 3 |
| 108 | 121 | Breakfast With Scot | Regent Releasing | $594 | $35,915 | 6 | 1 |
| 109 | - | Sixty Six | Universal Pictures, First Independent Pictures | $589 | $220,564 | 16 | 1 |
| 110 | 128 | Louise Bourgeois: The Spider, The Mistress and The Tangerine | N/A | $585 | $80,701 | 21 | 1 |
| 111 | 99 | Otto; or, Up with Dead People | Strand Releasing | $568 | $6,553 | 2 | 1 |
| 112 | 117 | God & Gays: Bridging the Gap | Indican Pictures | $567 | $4,490 | 4 | 1 |
| 113 | - | Dare Not Walk Alone | N/A | $387 | $52,052 | 28 | 1 |
| 114 | 92 | The Pool | N/A | $377 | $93,257 | 11 | 2 |
| 115 | 119 | Filth and Wisdom | IFC Films | $329 | $21,097 | 5 | 1 |
| 116 | - | Ice Blues: A Donald Strachey Mystery | Regent Releasing | $268 | $1,282 | 5 | 1 |
| 117 | 95 | Save Me | N/A | $246 | $75,335 | 11 | 1 |
| 118 | - | Fall of Hyperion | Regent Releasing | $133 | $1,028 | 5 | 1 |
| 119 | 123 | Baghead | Sony Pictures Classics | $90 | $140,016 | 23 | 1 |
| 120 | 129 | Whaledreamers | Monterey Media | $85 | $7,379 | 8 | 1 |
| 121 | - | The Amazing Truth About Queen Raquela | Regent Releasing | $69 | $5,364 | 5 | 1 |
| 122 | 132 | Moving Midway | First Run Features | $62 | $38,137 | 10 | 1 |